Alle artikelen en behandelingsprotocollen zijn volgens het zelfzorg principe geschreven. Bij zelfzorg is niet de arts of specialist maar de patiënt verantwoordelijk voor het correct uitvoeren van de behandeling. Toch adviseer ik patiënten om bij gezondheidsklachten eerst een arts te raadplegen. Een juiste diagnose is ook bij een zelfzorgtraject van onschatbare waarde. Als u reeds onder behandeling bent van een arts overleg dan met uw arts voordat u voedingssupplementen gaat gebruiken.

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Wetenschappelijke artikelen - FASE IV

Alle claims in dit boek zijn gebaseerd op wetenschappelijke studies. Bij elke claim is dan ook een verwijzing geplaatst naar het corresponderende wetenschappelijke artikel. Deze “verwijzingen” worden aangegeven met kleine cijfertjes in de tekst in mijn boek. Om het eenvoudiger te maken om deze verwijzingen terug te vinden wordt in dit referentie hoofdstuk dezelfde hoofdstukstructuur als in het boek aangehouden.

FASE IV: Avondeten aanpassen

  1. Voedingscentrum Vetwijzer
  2. The role of linoleic acid in endothelial cell gene expression. Relationship to atherosclerosis
    Our discoveries that linoleic acid can influence significantly the cytokine-mediated inflammatory response may open new fields in dietary intervention of atherosclerosis
  3. Involvement of CYP 2C9 in mediating the proinflammatory effects of linoleic acid in vascular endothelial cel
    Our data show that CYP 2C9 plays a key role in linoleic acid-induced oxidative stress and subsequent proinflammatory events in vascular endothelial cells by possibly causing superoxide generation through uncoupling processes
  4. Dietary alpha-linolenic acid is associated with reduced risk of fatal coronary heart disease, but increased prostate cancer risk: a meta-analysis
    This meta-analysis shows that consumption of ALA might reduce heart disease mortality. However, the association between high intake of ALA and prostate cancer is of concern and warrants further study
  5. Dietary intake of n-3 and n-6 fatty acids and the risk of prostate cancer
    Increased dietary intakes of ALA may increase the risk of advanced prostate cancer. In contrast, EPA and DHA intakes may reduce the risk of total and advanced prostate cancer
  6. Trans fatty acids and insulin resistance
    Since trans fatty acids (TFA) might interfere with cell membrane functions, there are reasons to believe that high TFA intakes could affect insulin sensitivity and consequently diabetes risk
  7. Dietary trans fatty acid intake is associated with increased fetal loss
    Since PPAR-gamma plays a pivotal role in placental biology and is down-regulated by TFAs, TFAs may be a reversible risk factor for fetal loss
  8. Trans fatty acids in maternal milk lead to cardiac insulin resistance in adult offspring
    Our data suggest that the consumption of hydrogenated fat, rich in TFAs, by the mothers during the lactation period caused cardiac insulin resistance in the adult progeny, thus reinforcing the hypothesis that early adaptations may cause deleterious consequences later in life
  9. Dietary fat intake and risk of type 2 diabetes in women
    These data suggest that total fat and saturated and monounsaturated fatty acid intakes are not associated with risk of type 2 diabetes in women, but that trans fatty acids increase and polyunsaturated fatty acids reduce risk
  10. Trans fatty acids - effects on systemic inflammation and endothelial function
    Consumption of trans fatty acids (TFA) predicts higher risk of coronary heart disease, sudden death, and possibly diabetes mellitus. These associations are greater than would be predicted by effects of TFA on serum lipoproteins alone
  11. Trans fatty acids and cardiovascular risk: a unique cardiometabolic imprint?
    Prospective observational studies demonstrate strong positive associations between TFA consumption and risk of myocardial infarction, coronary heart disease death, and sudden death.
  12. Association between serum trans-monounsaturated fatty acids and breast cancer risk in the E3N-EPIC Study
    A high serum level of trans-monounsaturated fatty acids, presumably reflecting a high intake of industrially processed foods, is probably one factor contributing to increased risk of invasive breast cancer in women
  13. Enkele belangrijke ontwikkelingen in de voedselconsumptie
    Ook de samenstelling van de vetzuren in de voeding vertoonde een gunstige ontwikkeling: het percentage verzadigde vetzuren en transvetzuren nam af tot respectievelijk ongeveer 14% en 1,7%. Toch is de inname nog steeds hoger dan de 10% en 0,8% die vanuit gezondheidskundig oogpunt aanvaardbaar wordt geacht. De veranderingen in consumptie hebben van 1987 tot 1997 geleid tot een verminderde inname van vitamines (vooral A, E, D en foliumzuur) en mineralen (zoals ijzer).
  14. The importance of the ratio of omega-6/omega-3 essential fatty acids
    Excessive amounts of omega-6 polyunsaturated fatty acids (PUFA) and a very high omega-6/omega-3 ratio, as is found in today's Western diets, promote the pathogenesis of many diseases, including cardiovascular disease, cancer, and inflammatory and autoimmune diseases
  15. Evolutionary aspects of diet, the omega-6/omega-3 ratio and genetic variation: nutritional implications for chronic diseases
    Anthropological and epidemiological studies and studies at the molecular level indicate that human beings evolved on a diet with a ratio of omega-6 to omega-3 essential fatty acids (EFA) of approximately 1 whereas in Western diets the ratio is 15/1 to 16.7/1
  16. The omega-6/omega-3 fatty acid ratio, genetic variation, and cardiovascular disease
    A high omega-6/omega-3 ratio, as is found in today's Western diets, promotes the pathogenesis of many chronic diseases, including cardiovascular disease
  17. Dietary modulation of omega-3/omega-6 polyunsaturated fatty acid ratios in patients with breast cancer
    Polyunsaturated fatty acids of the omega-6 (omega-6) class, as found in corn and safflower oils, can act as precursors for intermediates involved in the growth of mammary tumors when fed to animals, whereas polyunsaturated fatty acids of the omega-3 (omega-3) class, as found in fish oil, can inhibit these effects
  18. Modulation of omega-3/omega-6 polyunsaturated ratios with dietary fish oils in men with prostate cancer
    A short-term dietary intervention in men with prostate cancer leads to a significant increase in the omega-3/omega-6 fatty acid ratios in plasma and adipose tissue. The potential for this diet to prevent the development and progression of prostate cancer by way of altered COX-2 expression and prostaglandin production in prostatic tissue requires further study
  19. Increasing homicide rates and linoleic acid consumption among five Western countries, 1961-2000
    Clinical intervention trials and animal studies indicate that increasing dietary intakes of long chain n-3 FA or reducing linoleic acid intake may reduce aggressive and violent behaviors. Greater apparent consumption of linoleic acid correlated with higher rates of homicide mortality
  20. The Mediterranean diet: science and practice
    Both epidemiologic and metabolic studies suggest that individuals can benefit greatly by adopting elements of Mediterranean diets
  21. Secrets of the Mediterranean diet
    A recent study has once again confirmed that people who closely follow 'the Mediterranean Diet' live longer than other Europeans and Americans and the incidence of heart disease in Mediterranean countries is lower than in the United States
  22. Olive oil and longevity
    Several lines of evidence point to olive oil and the olive oil-centered Mediterranean diet as conducive to longevity
  23. Anti-inflammatory effect of virgin olive oil in stable coronary disease patients: a randomized, crossover, controlled trial
    Consumption of virgin olive oil, could provide beneficial effects in stable coronary heart disease patients as an additional intervention to the pharmacological treatment
  24. Antioxidant effect of virgin olive oil in patients with stable coronary heart disease: a randomized, crossover, controlled, clinical trial
    Consumption of VOO, rich in PC, could provide beneficial effects in CHD patients as an additional and complementary intervention to the pharmacological treatment
  25. The potential role of olive oil-derived MUFA in insulin sensitivity
    This review addresses the potential role of olive oil-derived MUFA in insulin sensitivity, particularly how dietary fat interacts with insulin resistance looking at whole body metabolic measures, as well as molecular effects
  26. MUFA-rich diet improves posprandial glucose, lipid and GLP-1 responses in insulin-resistant subjects
    Weight maintenance with a MUFA-rich diet improves HOMA-ir and fasting proinsulin levels in insulin-resistant subjects. Ingestion of a virgin olive oil-based breakfast decreased postprandial glucose and insulin concentrations, and increased HDL-C and GLP-1 concentrations as compared with CHO-rich diet
  27. Nutritional strategies in the prevention and treatment of metabolic syndrome
    Together, the evidence suggests that the components of diet currently recommended as "healthy" are likely also protective against MetS, including low saturated and trans fat (rather than low total fat) and balanced carbohydrate intake rich in dietary fiber
  28. Dietary treatment of the metabolic syndrome--the optimal diet
    In this respect, the specific effects of the quality of dietary fat are of great interest, given the considerable evidence in experimental animals that saturated fat in the diet may lead to insulin resistance. In man, there is indirect evidence that a higher saturated fat intake is associated with impaired insulin action
  29. Fatty acids and CHD
    Saturated and trans-fatty acids increase and both n-6 and n-3 PUFA decrease the risk of CHD
  30. Diet and lifestyle recommendations revision 2006: a scientific statement from the American Heart Association Nutrition Committee
    consume fish, especially oily fish, at least twice a week; limit intake of saturated fat to <7% of energy, trans fat to <1% of energy
  31. Dietary recommendations for children and adolescents: a guide for practitioners
    These general recommendations echo other recent public health dietary guidelines in emphasizing low intakes of saturated and trans fat
  32. Margarine's trans-fatty acid composition: modifications during the last decades and new trends
    Trans fatty acids isomers are formed during the hydrogenation process used in the food industry to harden oils. In the last decades there has been a great controversy about the consumption of margarine due to the levels of trans fatty acids they cont
  33. Home use of margarine is an important determinant of plasma trans fatty acid status: a biomarker study
    The home use of margarine, made with partially hydrogenated vegetable oils, is an important determinant of trans fatty acid exposure in New Zealand
  34. A review of omega-3 ethyl esters for cardiovascular prevention and treatment of increased blood triglyceride levels
    More importantly, two large studies showed reductions in clinical endpoints like sudden cardiac death or major adverse cardiac events. As a consequence, relevant cardiac societies recommend using 1 g/day of EPA and DHA for cardiovascular prevention, after a myocardial infarction and for prevention of sudden cardiac death
  35. Cardiovascular protective effects of n-3 polyunsaturated fatty acids with special emphasis on docosahexaenoic acid
    It is widely accepted that n-3 polyunsaturated fatty acids (PUFAs) rich in fish oils protect against several types of cardiovascular diseases such as myocardial infarction, arrhythmia, atherosclerosis, or hypertension
  36. Fatty acids and the prevention of coronary atherosclerosis
    Epidemiologic studies have shown an inverse correlation between consumption of fish or other sources of dietary n-3 fatty acids and cardiovascular events. Numerous mechanisms of action for the favorable effect of dietary n-3 fatty acids on factors implicated in the pathogenesis of atherosclerosis have been described
  37. Effect of medium-term supplementation with a moderate dose of n-3 polyunsaturated fatty acids on blood pressure in mild hypertensive patients
    These data indicate that 4 g/day of highly purified EPA + DHA ethyl esters are able to favorably affect BP in mild hypertensives
  38. Docosahexaenoic Acid but Not Eicosapentaenoic Acid Lowers Ambulatory Blood Pressure and Heart Rate in Humans
    The results of this study suggest that DHA is the principal 3 fatty acid in fish and fish oils that is responsible for their BP- and HR-lowering effects in humans. These results have important implications for human nutrition and the food industry
  39. n-3 long-chain polyunsaturated fatty acids in type 2 diabetes: a review
    Historically, epidemiologic studies have reported a lower prevalence of impaired glucose tolerance and type 2 diabetes in populations consuming large amounts of the n-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) found mainly in fish
  40. N-3 long chain polyunsaturated fatty acids: a nutritional tool to prevent insulin resistance associated to type 2 diabetes and obesity?
    Indeed, fish oil reduces insulin response to oral glucose without altering the glycaemic response, abolishes extraggression at times of mental stress, decreases the activation of sympathetic activity during mental stress and also decreases plasma triglycerides. These effects are encouraging in the perspective of prevention of insulin resistance but further clinical and basic studies must be designed to confirm and complete our knowledge in this field
  41. Low glycaemic index or low glycaemic load diets for overweight and obesity
    In studies comparing ad libitum LGI diets to conventional restricted energy low-fat diets, participants fared as well or better on th LGI diet, even though they could eat as much as desired
  42. Medium chain triglycerides
    Medium chain triglycerides (MCTs) are medium-chain (6 to 12 carbons) fatty acid esters of glycerol. MCTs passively diffuse from the GI tract to the portal system (longer fatty acids are absorbed into the lymphatic system) without requirement for modification like long chain fatty acids or very long chain fatty acids do. In addition MCTs do not require bile salts for digestion. Rich sources of MCTs include coconut oil and palm kernel oils and are also found in camphor tree drupes
  43. Coconut fats
    Coconut fats account for 80% of the fat intake among Sri Lankans. Yet most of the saturated fats in coconut are medium chain fatty acids whose properties and metabolism are different to those of animal origin. Medium chain fatty acids do not undergo degradation and re-esterification processes and are directly used in the body to produce energy
  44. Medium chain triglycerides (MCT) in aging and arteriosclerosis
    The Demographic Yearbook of the United Nations (1978) reported that Sri Lanka has the lowest death rate from ischemic heart disease. Sri Lanka is the only of the countries giving reliable data where coconut oil (containing over 50% medium chain fatty acids) is the main dietary fat
  45. Consumption of an oil composed of medium chain triacyglycerols, phytosterols, and N-3 fatty acids improves cardiovascular risk profile in overweight women
    In conclusion, despite equivocal effects on homocysteine levels, consumption of a functional oil composed of MCT, phytosterols, and n-3 fatty acids for 27 days improves the overall cardiovascular risk profile of overweight women
  46. Dietary fatty acids and insulin resistance
    On the other hand, medium and long-chain fatty acid intakes are associated with insulin sensitivity, as are high intakes of omega-3 fatty acids
  47. Dietary medium- and long-chain triacylglycerols accelerate diet-induced thermogenesis in humans
    Increase in DIT after ingesting the liquid meal with MLCT during 6h was significantly greater than with LCT (P<0.05). The results suggest that the substitution of MLCT for cooking oil is useful to control body weigh and fat in subjects
  48. Comparison of diet-induced thermogenesis of foods containing medium- versus long-chain triacylglycerols
    These results suggest that, in healthy humans, the intake of 5-10 g of MCT causes larger diet-induced thermogenesis than that of LCT, irrespective of the form of meal containing the MCT.
  49. The application of medium-chain fatty acids: edible oil with a suppressing effect on body fat accumulation
    Long-term clinical trials have demonstrated that MLCT and MCT result in less body fat accumulation in humans. MLCT oil has been approved as FOSHU (Food for Specified Health Use) for use as cooking oil with a suppressing effect on body fat accumulation
  50. Research on the nutritional characteristics of medium-chain fatty acids
    Recently, long-term clinical trials have demonstrated that MLCT and MCT result in less body fat-deposition. MLCT oil (Trade name: Healthy Resseta) is safe and can be substitute for common edible vegetable oils. Healthy Resseta has been approved as FOSHU (Food for Specified Health Use), by the Ministry of Health, Labour and Welfare of Japan in December 2002 for use as a cooking oil with a suppressing effect on body fat accumulation. Healthy Resseta is widely sold in Japan
  51. Voedingscentrum Verantwoord frituren
    De VWA heeft in 2007 onderzoek gedaan bij snackbars en cafetaria’s. Wat blijkt? De helft van de horecabedrijven gebruikt nog vast frituurvet, de andere helft is al overgestapt op vloeibaar frituurvet. Sinds 2006 stijgt het aantal horecaondernemers dat met vloeibaar vet frituurt niet. Dat is jammer want vloeibaar frituurvet bevat minder verzadigd vet en transvet en is daarom een betere keus. Dus: Ga je naar de horeca? Kijk dan of het logo Verantwoord Frituren aan de gevel hangt. Dat betekent dat er vloeibaar vet wordt gebruikt. Of vraag ernaar in de zaak.
  52. Over de campagne verantwoord frituren
    Ondanks het feit dat vloeibaar frituurvet de beste keuze is voor de gezondheid van de klant, gebruikt nog maar één op de tien horecaondernemers vloeibaar frituurvet. De doelstelling van de campagne is om het aantal gebruikers van vloeibaar frituurvet in de
  53. Dietary advanced lipid oxidation endproducts are risk factors to human health
    The oxidation of unsaturated fatty acids results in significant generation of dietary advanced lipid oxidation endproducts (ALEs) which are in part cytotoxic and genotoxic compounds. Some of the dietary ALEs, which are absorbed from the gut to the circulatory system, seems to act as injurious chemicals that activate an inflammatory response which affects not only circulatory system but also organs such as liver, kidney, lung, and the gut itself. We believe that repeated consumption of oxidized fat in the diet poses a chronic threat to human health
  54. Chemistry of deep-fat frying oils
    High frying temperature, the number of fryings, the contents of free fatty acids, polyvalent metals, and unsaturated fatty acids of oil decrease the oxidative stability and flavor quality of oil
  55. Dietary omega-3 fatty acids for women
    The only adequate sources are rapeseed oil (canola), walnuts and so-called "omega-3" eggs (similar to wild-type or Cretan eggs). The amounts of EPA and DHA in the diet vary greatly from person to person. The only good sources are fish and seafood, together with "omega-3" eggs.
  56. Extract of Salacia oblonga lowers acute glycemia in patients with type 2 diabetes
    Both doses of the Salacia extract significantly lowered the postprandial positive area under the glucose curve (14% for the 240 mg extract and 22% for the 480 mg extract) and the adjusted peak glucose response (19% for the lower dose and 27% for the higher dose of extract) to the control meal. In addition, both doses of the herbal extract significantly decreased the postprandial insulin response, lowering both the positive area under the insulin curve and the adjusted peak insulin response (14% and 9%, respectively, for the 240 mg extract; 19% and 12%, respectively, for the 480 mg extract) in comparison with the control meal
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